Expériences professionnelles
Stagiaire
Société Générale
De Avril 2024 à Septembre 2024
Introduction des risques ESG dans le calcul de la probabilité de défaut des grandes entreprises. Le stage consistera à s'appropier du modèle de probabilité de défaut de la société générale. Ensuite de proposer une méthodologie pour intégrer les risques ESG.
Research assistant
Inria
De Juin 2023 à Août 2023
Ebola Virus Disease (EVD) is a life-threatening illness associated with high mortality rates. To combat the 2014-2016 West Africa Ebola epidemic, vaccines like Ad26.ZEBOV/MVA-BN-Filo (Ad26-MVA) and rVSVΔG-ZEBOV-GP (rVSV) were developed to elicit strong immune responses. This study aimed to characterize the post-vaccination antibody responses for these vaccines.
We analyzed data from 2,000 participants in the PREVAC-UP trial. For the Ad26-MVA vaccine, a non-replicative biphasic model was most appropriate, with estimated antibody secretion rates of 1.87. In contrast, a replicative biphasic model was chosen for rVSV, which had a notably higher antibody secretion rate of 14, likely due to its replicative nature. The rates of long-lived and short-lived antibody-secreting cells also significantly varied between the two vaccines.
Using the SAMBA algorithm, we identified factors like age, gender, country, and laboratory conditions that affected immune response variability. While the impacts of age and gender were consistent with prior research, differences related to country and laboratory conditions suggest that environmental or genetic factors may contribute to population-level variability.
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